Wednesday, October 3, 2012

What is penicillin and Source of Penicillin



PENICILLINS

It is the oldest member of bactericidal antibiotics . Sir Alexander  Fleming discovered penicillin in 1928.
In 1940 Chain , Folery and their  associates first produce significant quantities  of penicillin from cultures of Penicillium  notatum . 
Penicillins are lipid insoluble. 
penicillin
Cannot cross the blood brain barrier.
Can cross the placental barrier.

Source of Penicillin :
1. Natural : Penicillum notatum (previously)
penicillin
Penicillium chrysogennum (now a day )
2. Synthetic.
3. Semisynthetic.

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