Mechanism of
action of Penicillin
Penicillin first binds with specific penicillin binding
proteins (PBPs) that serves as drug receptor on bacteria. Then –
Ø
Penicillin acts as a selective inhibitor of
transpeptidase enzyme . So the transpeptidation (cross-linking) reaction is
inhibited and peptidoglycine synthesis is blocked. As a result a fragile cell
membrane is formed and thus cell membrane permeability increased . Now fluid
goes inside the cell due to hypertonic internal osmotic pressure . The bacterial
cell becomes swollen and ultimately the cell explodes and lysed.
penicillin |
Ø
Penicillin actives an autolytic enzyme by
removing or inactivating the inhibitor
of autolytic enzyme in the cell wall – activated autolytic enzyme causes
lysis of the bacterial cell wall in isotonic environment –Death of the bacteria .
0 comments:
Post a Comment